Collect. Czech. Chem. Commun.
1984, 49, 2807-2815
https://doi.org/10.1135/cccc19842807
Kinetic analysis of reactions of phenylhydrazonopropanedinitriles with thiols
Marián Antalíka, Ernest Šturdíka, Oldřich Pytelab, Ľudovít Drobnicaa and Pavol Suloa
a Department of Technical Microbiology and Biochemistry, Faculty of Chemical Technology, Slovak Institute of Technology, 812 37 Bratislava
b Department of Organic Chemistry, Institute of Chemical Technology, 532 10 Pardubice
Individual author index pages
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Kinetics and Mechanism of Acid Catalysed Hydration of α-Methylstyrenes
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Conformational Transitions of Ferricytochrome c in Strong Inorganic Acids
2006, Vol. 71, Issue 11-12, pp. 1627–1641 [Abstract] - Jan Pícha, Radek Cibulka*, František Liška, Patrik Pařík and Oldřich Pytela
Reparametrization and/or Determination of Hammett, Inductive, Mesomeric and AISE Substituent Constants for Five Substituents: N+(CH3)3, CH2N+(CH3)3, CH2Py+, CH2SO2CH3 and PO(OCH3)2
2004, Vol. 69, Issue 12, pp. 2239–2252 [Abstract] - Jan Pícha*, Radek Cibulka, František Hampl, František Liška, Patrik Pařík and Oldřich Pytela
Reactivity of p-Substituted Benzaldoximes in the Cleavage of p-Nitrophenyl Acetate: Kinetics and Mechanism
2004, Vol. 69, Issue 2, pp. 397–413 [Abstract] - Oldřich Pytela* and Jiří Kulhánek
Ortho Effect in Dissociation of Benzoic Acids with Electron-Accceptor Substituents Using the AISE Theory; Relation to para Substitution and Solvent
2002, Vol. 67, Issue 5, pp. 596–608 [Abstract] - Oldřich Pytela*, Jiří Kulhánek, Eva Jirásková and Taťjana Nevěčná
Construction of Interconnected Acidity Functions Based on ortho Substituted Anilines and N-Methylanilines as Indicators
2001, Vol. 66, Issue 11, pp. 1638–1658 [Abstract] - Jiří Kulhánek*, Oldřich Pytela and Antonín Lyčka
Chemometrical Analysis of Substituent Effects. XIII. Comparison of Substituent Effects on Dissociation and Chemical Shift in 13C NMR Spectra of Mono- and Disubstituted Benzoic Acids
2000, Vol. 65, Issue 1, pp. 106–116 [Abstract] - Oldřich Pytela* and Ondřej Prusek
Chemometric Analysis of Substituent Effects. XII. Application of Relationship Between 2- and 4-Substitution of Benzene Ring to Study ortho Effect in Selected Compounds with Different Reaction Centres
1999, Vol. 64, Issue 10, pp. 1617–1628 [Abstract] - Eva Jirásková, Jiří Kulhánek, Taťjana Nevěčná* and Oldřich Pytela
Construction and Chemometric Analysis of Acidity Function in Perchloric Acid
1999, Vol. 64, Issue 8, pp. 1253–1261 [Abstract] - Petr Mitaš, Jaromír Kaválek and Oldřich Pytela
Dissociation of Amides in Strongly Basic Medium of Sodium Methoxide in Dimethyl Sulfoxide-Methanol Mixtures
1997, Vol. 62, Issue 10, pp. 1562–1576 [Abstract] - Marek Janík, Vladimír Macháček and Oldřich Pytela
Kinetics of Cyclization of Methyl S-(2,4,6-Trinitrophenyl)mercaptoacetate to 2-Methoxycarbonyl-5,7-dinitrobenzo[d]thiazol-3-oxide
1997, Vol. 62, Issue 9, pp. 1429–1445 [Abstract] - Jiří Kulhánek and Oldřich Pytela
Chemometric Analysis of Substituent Effects. XI. Solvent Effects on Dissociation of 2,6-Disubstituted Benzoic Acids
1997, Vol. 62, Issue 6, pp. 913–924 [Abstract] - Oldřich Pytela
A New Iterative Method of Construction of the Hammett Acidity Function
1997, Vol. 62, Issue 4, pp. 645–655 [Abstract] - Oldřich Pytela
Chemometric Analysis of Substituent Effects. X. Unification and Reparametrization of Substituent Constants in Hammett-Type Equations by Means of Alternative Interpretation of Substituent Effects (AISE)
1996, Vol. 61, Issue 8, pp. 1191–1204 [Abstract] - Oldřich Pytela and Aleš Halama
Steric Effects in Acid-Catalyzed Decomposition and Base-Catalyzed Cyclization of 1-(2-Alkoxycarbonylphenyl)-3-phenyltriazenes
1996, Vol. 61, Issue 5, pp. 751–763 [Abstract] - Oldřich Pytela
Chemometric Analysis of Substituent Effects. IX. Alternative Interpretation of Substituent Effects (AISE) - Orthogonal Model
1996, Vol. 61, Issue 5, pp. 704–712 [Abstract] - Oldřich Pytela
Chemometric Analysis of Substituent Effects. VIII. Alternative Interpretation of Substituent Effects (AISE)
1995, Vol. 60, Issue 9, pp. 1502–1528 [Abstract] - Oldřich Pytela and Aleš Halama
Chemometric Analysis of Substituent Effects. VII. Inductive Effect as a Basic Substituent Effect. Isoeffect Substituent Constant
1995, Vol. 60, Issue 8, pp. 1316–1332 [Abstract] - Jiří Kulhánek and Oldřich Pytela
Chemometric Analysis of Substituent Effects. VI. A Study of ortho Effect in Dissociation of 2,6-Disubstituted Benzoic Acids
1995, Vol. 60, Issue 5, pp. 829–840 [Abstract] - Dana Mazagová, Pavol Kristian, Gejza Suchár, Ján Imrich and Marián Antalík
Kinetics of Reactions of 9-Isothiocyanatoacridine with Aromatic and Aliphatic Amines and Fluorescence Properties of the 1-Acridin-9-yl-3-alkyl(aryl)thioureas Obtained
1994, Vol. 59, Issue 12, pp. 2632–2640 [Abstract] - Oldřich Pytela and Taťjana Nevěčná
Kinetics and Mechanism of Decomposition of 1,3-Bis(4-methylphenyl)triazene Catalyzed with Substituted Benzoic Acids in 25% Aqueous Methanol-General or Specific Catalysis?
1994, Vol. 59, Issue 9, pp. 2029–2041 [Abstract] - Oldřich Pytela and Josef Liška
Chemometrical Analysis of Substituent Effects. V. ortho Effect
1994, Vol. 59, Issue 9, pp. 2005–2021 [Abstract] - Danica Sabolová, Dana Mazagová, Pavol Kristian, Marián Antalík, Dušan Podhradský and Ján Imrich
Fluorescence Reagents for Labelling of Biomolecules. Part III. Study of the Reactions of 2- and 4-Substituted 9-Isothiocyanatoacridines with Glycine
1994, Vol. 59, Issue 7, pp. 1682–1690 [Abstract] - Oldřich Pytela, Jiří Kulhánek and Miroslav Ludwig
Chemometrical Analysis of Substituent Effects. IV. Additivity of Substituent Effects in Dissociation of 3,5-Disubstituted Benzoic Acids in Organic Solvents
1994, Vol. 59, Issue 7, pp. 1637–1644 [Abstract] - Taťjana Nevěčná, Vojtěch Bekárek and Oldřich Pytela
A Study of Effects of Temperature and Medium on Reaction of Triethylamine with Ethyl Bromide
1994, Vol. 59, Issue 6, pp. 1384–1391 [Abstract] - Oldřich Pytela, Jiří Kulhánek, Miroslav Ludwig and Václav Říha
Chemometrical Analysis of Substituent Effects. III. Additivity of Substituent Effects in Dissociation of 3,4-Disubstituted Benzoic Acids in Organic Solvents
1994, Vol. 59, Issue 3, pp. 627–638 [Abstract] - Miroslav Ludwig, Pavla Valášková and Oldřich Pytela
Kinetics and Mechanism of Acid Catalyzed Decomposition of 1-Phenyl-3,3-dialkyltriazenes
1994, Vol. 59, Issue 2, pp. 401–411 [Abstract] - Miroslav Ludwig, Jan Petržílek, Jiří Kulhánek and Oldřich Pytela
Effects of Substituents and Medium on Acidity of α,α-Bis(butylsulfonyl)toluenes
1994, Vol. 59, Issue 2, pp. 391–400 [Abstract] - Oldřich Pytela
Chemometric Analysis of Substituent Effects. II. Relation Between Hammett Substituent Constants σm and σp and a New Model for Quantitative Description of Substituent Effects
1994, Vol. 59, Issue 2, pp. 381–390 [Abstract] - Dušan Podhradský, Peter Oravec, Marián Antalík and Pavol Kristian
Fluorescence Reagents for Labelling of Biomolecules. Part II. Reactions of 9-Isothiocyanatoacridine with Amino Acids
1994, Vol. 59, Issue 1, pp. 213–221 [Abstract] - Dana Mazagová, Danica Sabolová, Pavol Kristian, Ján Imrich, Marián Antalík and Dušan Podhradský
Fluorescence Reagents for Labelling of Biomolecules. Part I. Synthesis and Spectral Characterization of 2- and 4-Substituted 9-Isothiocyanatoacridines
1994, Vol. 59, Issue 1, pp. 203–212 [Abstract] - Oldřich Pytela
Chemometric Analysis of Substituent Effects. I. Substituent Effects on the Dissociation of Monosubstituted Benzoic Acids
1994, Vol. 59, Issue 1, pp. 159–174 [Abstract] - Štefan Baláž, Ernest Šturdík, Regina Ujhelyová, Dušan Valigura, Michal Uher, Miroslav Veverka, Václav Konečný, Jana Adamcová, Peter Michalík and Július Brtko
Biologically Important Physicochemical Properties of Kojic Acid Derivatives
1993, Vol. 58, Issue 3, pp. 693–701 [Abstract] - Katarína Škvareninová, Štefan Baláž, Ernest Šturdík, Miroslav Veverka, Jana Adamcová and Jana Olexová
Biologically Important Physicochemical Properties of Some Cephalosporins
1992, Vol. 57, Issue 8, pp. 1739–1746 [Abstract] - Oldřich Pytela, Taťjana Nevěčná and Jaromír Kaválek
Reactivity of proton and general acid with 1,3-bis-(4-methylphenyl)triazene in aqueous methanol
1990, Vol. 55, Issue 11, pp. 2701–2706 [Abstract] - Oldřich Pytela and Zdeněk Bahník
Synthesis, kinetics and mechanism of cyclization of 1-(2-aryloxycarbonylphenyl)-3-phenyltriazenes
1990, Vol. 55, Issue 11, pp. 2692–2700 [Abstract] - Oldřich Pytela, Jaroslava Hálová and Miroslav Ludwig
Interpretation of chromatographic characteristics of mobile phase in liquid chromatography by means of solvent parameters
1990, Vol. 55, Issue 11, pp. 2629–2635 [Abstract] - Oldřich Pytela and Vladimír Dlouhý
Synthesis and cyclization kinetics and mechanism of 1-(2-ethoxycarbonylphenyl)-3-aryltriazenes. Kinetic acidity function of sodium methoxide in methanol
1990, Vol. 55, Issue 10, pp. 2468–2474 [Abstract] - Oldřich Pytela
A new classification of solvents based on chemometric empirical scale of parameters
1990, Vol. 55, Issue 3, pp. 644–652 [Abstract] - Oldřich Pytela
Additive-multiplicative description of extrathermodynamic relations: Application to solvent effect
1990, Vol. 55, Issue 3, pp. 634–643 [Abstract] - Oldřich Pytela, Taťjana Nevěčná and Miroslav Ludwig
Solvent effects on kinetics and mechanism of acid-catalyzed decomposition of 1,3-bis(4-methylphenyl)-triazene II. Reactions in aprotic solvents
1990, Vol. 55, Issue 1, pp. 156–164 [Abstract] - Taťjana Nevěčná, Oldřich Pytela, Miroslav Ludwig and Jaromír Kaválek
Solvent effects on kinetics and mechanism of acid-catalyzed decomposition of 1,3-bis(4-methylphenyl)triazene I. Reactions in alcohols
1990, Vol. 55, Issue 1, pp. 147–155 [Abstract] - Oldřich Pytela
Determination of number of linear latent variables in a set of experimental chemical data
1990, Vol. 55, Issue 1, pp. 42–54 [Abstract] - Marián Antalík, Ernest Šturdík, Dušan Podhradský, Ingrid Poleková and Ľudovít Drobnica
Kinetics analysis of the decay of phenylhydrazonopropanedinitrile addition products with thiols in aqueous solutions
1989, Vol. 54, Issue 12, pp. 3387–3396 [Abstract] - Vítězslav Zima, Oldřich Pytela, Jaromír Kaválek and Miroslav Večeřa
Reactivity of nucleophiles in dimethyl sulfoxide and its comparison with nucleophilic reactivity in protic medium
1989, Vol. 54, Issue 10, pp. 2715–2720 [Abstract] - Oldřich Pytela, Josef Jirman and Antonín Lyčka
Chemometrical analysis of substituent effects on 13C and 15N NMR chemical shifts in 1-aroyl-3-substituted thioureas
1989, Vol. 54, Issue 9, pp. 2399–2407 [Abstract] - Oldřich Pytela
New statistical parameters for description of solvent effect
1989, Vol. 54, Issue 1, pp. 136–150 [Abstract] - Oldřich Pytela and Vítězslav Zima
Nucleophilicity and its parametrization
1989, Vol. 54, Issue 1, pp. 117–135 [Abstract] - Oldřich Pytela
Empirical approach to description of solvent effect on processes in solutions: A review
1988, Vol. 53, Issue 7, pp. 1333–1423 [Abstract] - Ernest Šturdík, Štefan Baláž, Edita Ďurčová, Marián Antalík, Pavol Sulo, Maria Šturdíková and Vladimír Mikeš
Subcellular and cellular studies on relationship between structure and uncoupling effect of phenylhydrazonopropanedinitriles on oxidative phosphorylation
1988, Vol. 53, Issue 5, pp. 1094–1101 [Abstract] - Vítězslav Zima, Oldřich Pytela and Miroslav Večeřa
A study of nucleophilicity in selected systems
1988, Vol. 53, Issue 4, pp. 814–821 [Abstract] - Oldřich Pytela and Miroslav Ludwig
A description of effect of composition of mixed binary solvents on processes in solutions
1988, Vol. 53, Issue 4, pp. 671–685 [Abstract] - Ľubomír Kluka, Ernest Šturdík, Štefan Baláž, Dušan Kordík, Michal Rosenberg, Marián Antalík and Jozef Augustín
Membrane proton transport mediated by phenylhydrazonopropanedinitriles
1988, Vol. 53, Issue 1, pp. 186–197 [Abstract] - Miroslav Ludwig, Oldřich Pytela, Helena Javůrková and Miroslav Večeřa
Analysis of substituent and solvent effects on dissociation of N-phenylbenzenesulphonamides
1987, Vol. 52, Issue 12, pp. 2900–2908 [Abstract] - Ernest Šturdík, Edita Ďurčová, Vladimír Mikeš, Vladimír Dadák, Štefan Baláž, Pavol Sulo and Marián Antalík
Acidobasicity, reactivity, lipophilicity, and ability of phenylhydrazonopropanedinitriles to disturb the membrane potential
1987, Vol. 52, Issue 11, pp. 2819–2825 [Abstract] - Oldřich Pytela, Petr Svoboda and Miroslav Večeřa
A mathematical modelling of acid catalyzed decomposition of 3-methyl-1,3-diphenyltriazene
1987, Vol. 52, Issue 10, pp. 2492–2499 [Abstract] - Petr Svoboda, Oldřich Pytela and Miroslav Večeřa
Kinetics and mechanism of acid catalyzed decomposition of substituted 1,3-diphenyltriazenes
1987, Vol. 52, Issue 9, pp. 2217–2224 [Abstract] - Oldřich Pytela, Martin Kaska, Miroslav Ludwig and Miroslav Večeřa
Solvolysis kinetics and mechanism of substituted 3-acetyl-1,3-diphenyltriazenes in acid medium; Kinetic acidity function
1987, Vol. 52, Issue 9, pp. 2212–2216 [Abstract] - Ernest Šturdík, Marián Antalík and Ľudovít Drobnica
Reversibility of reactions of phenylhydrazonopropanedinitriles with thiols
1987, Vol. 52, Issue 2, pp. 437–442 [Abstract] - Štefan Baláž, Daniel Végh, Ernest Šturdík, Jozef Augustín, Tibor Liptaj and Jaroslav Kováč
Substitution reactions of some (5-nitro-2-furyl)ethylene derivatives with thiols
1987, Vol. 52, Issue 2, pp. 431–436 [Abstract] - Michal Rosenberg, Štefan Baláž, Ernest Šturdík and Anton Kuchár
Reactivity of 2-furylethylenes with nucleophilic groups and its biological significance
1987, Vol. 52, Issue 2, pp. 425–430 [Abstract] - Oldřich Pytela, Miroslav Ludwig and Miroslav Večeřa
The Hammett substituent constants and effects of medium
1986, Vol. 51, Issue 10, pp. 2143–2150 [Abstract] - Miroslav Ludwig, Václav Baron, Karel Kalfus, Oldřich Pytela and Miroslav Večeřa
Dissociation constants of substituted benzoic acids in water and in organic solvents
1986, Vol. 51, Issue 10, pp. 2135–2142 [Abstract] - Miroslav Ludwig, Oldřich Pytela and Miroslav Večeřa
Solvent effects on dissociation of substituted benzenesulphonamides in acetone, 1,2-dichloroethane, tetramethylene sulphone, pyridine and some aqueous organic solvent mixtures
1986, Vol. 51, Issue 9, pp. 1948–1957 [Abstract] - Oldřich Pytela, Stanislava Štumrová, Miroslav Ludwig and Miroslav Večeřa
Kinetic acidity function and solvolysis of 3-hydroxy-1,3-diphenyltriazenes
1986, Vol. 51, Issue 3, pp. 564–572 [Abstract] - Petr Svoboda, Oldřich Pytela and Miroslav Večeřa
Kinetics of acid catalyzed decomposition of substituted 1,3-diphenyl-3-methyltriazenes
1986, Vol. 51, Issue 3, pp. 553–563 [Abstract] - Oldřich Pytela, Václav Vala, Miroslav Ludwig and Miroslav Večeřa
Modeling of hydrolysis mechanism of 3-hydroxytriazenes in strongly acidic medium
1986, Vol. 51, Issue 2, pp. 347–357 [Abstract] - Ernest Šturdík, Marián Antalík, Pavol Sulo, Štefan Baláž, Edita Ďurčová and Ľudovít Drobnica
Relationships among structure, reactivity towards thiols and basicity of phenylhydrazonopropanedinitriles
1985, Vol. 50, Issue 9, pp. 2065–2076 [Abstract] - Štefan Baláž, Anton Kuchár, Ernest Šturdík, Michal Rosenberg, Ladislav Štibrányi and Dušan Ilavský
Interphase distribution of 2-furylethylenes
1985, Vol. 50, Issue 8, pp. 1642–1647 [Abstract] - Ernest Šturdík, Štefan Baláž, Marián Antalík and Pavol Sulo
Lipophilic-hydrophilic properties and retention of phenylhydrazonopropanedinitriles by biological systems
1985, Vol. 50, Issue 2, pp. 538–550 [Abstract] - Michal Rosenberg, Ernest Šturdík, Tibor Liptaj, Juraj Bella, Daniel Végh, František Považanec and Vladimír Sitkey
Reactions of 1-(5-nitro-2-furyl)-2-nitroethylene with amino and hydroxy groups
1985, Vol. 50, Issue 2, pp. 470–481 [Abstract] - Pavol Sulo, Ernest Šturdík, Tibor Liptaj, Tibor Jakubík and Marián Antalík
Structure characterization of reaction products from phenylhydrazonopropanedinitrile and thiols
1985, Vol. 50, Issue 2, pp. 375–382 [Abstract] - Miroslav Ludwig, Oldřich Pytela and Miroslav Večeřa
Solvent effect in dissociation of substituted benzenesulphonamides in dimethylformamide, dimethyl sulphoxide, and acetonitrile
1984, Vol. 49, Issue 11, pp. 2593–2601 [Abstract] - Viktor Vrábel, Ernest Šturdík, Michal Dunaj-Jurčo, Jan Lokaj and Ján Garaj
Crystal and molecular structure of carbonylcyanide-4-chlorophenylhydrazone(4-chlorophenylhydrazonopropanedinitrile)
1984, Vol. 49, Issue 10, pp. 2363–2370 [Abstract] - Štefan Baláž, Ernest Šturdík and Bohumil Škárka
Mathematical description of nonequilibrium passive transport in biosystems
1984, Vol. 49, Issue 6, pp. 1382–1389 [Abstract] - Miroslav Ludwig, Oldřich Pytela, Karel Kalfus and Miroslav Večeřa
Dissociation of substituted benzenesulphonamides in water, methanol and ethanol
1984, Vol. 49, Issue 5, pp. 1182–1192 [Abstract] - Oldřich Pytela, Miroslav Pilný and Miroslav Večeřa
Substituent effect on solvolysis of 3-acetyl-1,3-diphenyltriazenes
1984, Vol. 49, Issue 5, pp. 1173–1181 [Abstract] - Petr Svoboda, Oldřich Pytela and Miroslav Večeřa
Solvent effect - Classification of parameters describing influence of solvents
1983, Vol. 48, Issue 11, pp. 3287–3306 [Abstract] - Oldřich Pytela and Pavel Vetešník
Dissociation constants of monosubstituted diphenylamines and an optimized construction of acidity function
1983, Vol. 48, Issue 8, pp. 2368–2375 [Abstract] - Tibor Liptaj, Ernest Šturdík and Pavol Sulo
Structure of „carbonyl cyanide phenylhydrazones" as evidenced by multinuclear NMR
1983, Vol. 48, Issue 6, pp. 1647–1650 [Abstract] - Ernest Šturdík, Ľudovít Drobnica and Štefan Baláž
Reactions of 2-furylethylenes with thiols in vivo
1983, Vol. 48, Issue 1, pp. 336–345 [Abstract] - Ernest Šturdík, Ľudovít Drobnica and Štefan Baláž
Interactions of 2-furylethylenes with thiol enzymes
1983, Vol. 48, Issue 1, pp. 327–335 [Abstract] - Štefan Baláž, Ernest Šturdík and Ľudovít Drobnica
Biochemically important reactions of 2-furylethylenes. Characterization of the reactivity towards thiols
1982, Vol. 47, Issue 6, pp. 1659–1666 [Abstract] - Ernest Šturdík, Tibor Liptaj, Štefan Baláž and Ľudovít Drobnica
Biochemically important reactions of 2-furylethylenes. Reactions with low-molecular thiols
1982, Vol. 47, Issue 5, pp. 1523–1529 [Abstract] - Miroslav Ludwig, Oldřich Pytela and Miroslav Večeřa
Salt effect in hydrolysis of 3-acyl-1,3-diphenyltriazenes
1981, Vol. 46, Issue 12, pp. 3104–3109 [Abstract] - Oldřich Pytela, Petr Svoboda and Miroslav Večeřa
Solvent effect as a criterion of solvolysis mechanism. Solvolysis of 3-acyl-1,3-diphenyltriazenes
1981, Vol. 46, Issue 9, pp. 2091–2103 [Abstract] - Erhard Lejdar, Oldřich Pytela, Miroslav Večeřa and Pavel Vetešník
Reaction of 1,3-diphenyltriazene with phenyl isocyanate. Solvent effect, activation parameters and kinetic isotopic effect
1981, Vol. 46, Issue 6, pp. 1376–1382 [Abstract] - Oldřich Pytela, Miroslav Večeřa and Pavel Vetešník
Calculation of isokinetic temperature of non-catalyzed hydrolysis of substituted 3-(N-methylcarbamoyl)-1,3-diphenyltriazenes
1981, Vol. 46, Issue 4, pp. 898–905 [Abstract] - Oldřich Pytela, Miroslav Večeřa and Pavel Vetešník
Substituent effects in hydrolysis of 3-carbamoyl-1,3-diphenyltriazenes
1980, Vol. 45, Issue 7, pp. 2108–2119 [Abstract] - Blanka Plandorová, Oldřich Pytela, Miroslav Večeřa and Pavel Vetešník
Reactions of substituted 1,3-diphenyltriazenes with phenyl isocyanates. Catalysis and substituent effects
1980, Vol. 45, Issue 4, pp. 1279–1289 [Abstract] - Oldřich Pytela, Miroslav Večeřa and Pavel Vetešník
Hydrolysis kinetics and mechanism of acyl-1,3-diphenyltriazenes
1980, Vol. 45, Issue 4, pp. 1269–1278 [Abstract]
