Collect. Czech. Chem. Commun. 1989, 54, 1370-1375
https://doi.org/10.1135/cccc19891370

Some approaches to the synthesis of sulbactam

Suren Husineca, Deana Dragovića,b, Zdenka Stokićc and Josipa Kojićc

a Institute of Chemistry, Faculty of Science, University of Belgrade, Studentski trg 16, P.O. Box 550, YU-11001, Belgrade, Yugoslavia
b Institute of Chemistry, Technology and Metallurgy, Faculty of Science, University of Belgrade, Studentski trg 16, P.O. Box 550, YU-11001, Belgrade, Yugoslavia
c Research Department, Galenika Pharmaceutical Co., 29 Novembra 111, 11000 Belgrade, Yugoslavia

Abstract

A study on the synthesis of penicillanic acid 1,1-dioxide, Sulbactam, was carried out. Two reliable convergent synthetic routes to this β-lactamase inhibitor starting from penicillin G potassium salt and 6-aminopenicillanic acid have been developed.