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Collect. Czech. Chem. Commun. 1995, 60, 2189-2199
https://doi.org/10.1135/cccc19952189

Cytochrome P-450 and Peroxidase Oxidize Detoxication Products of Carcinogenic Aristolochic Acids (Aristolactams) to Reactive Metabolites Binding to DNA in vitro

Marie Stiborováa, Eva Freib, Heinz H. Schmeiserb and Manfred Wiesslerb

a Department of Biochemistry, Charles University, 128 40 Prague 2, Czech Republic
b Department of Molecular Toxicology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

Crossref Cited-by Linking

  • Au Chun-Kit, Ham Yat-Hing, Chan Wan: Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy. Chem. Res. Toxicol. 2023, 36, 322. <https://doi.org/10.1021/acs.chemrestox.2c00415>
  • Michl Johanna, Ingrouille Martin J., Simmonds Monique S. J., Heinrich Michael: Naturally occurring aristolochic acid analogues and their toxicities. Nat. Prod. Rep. 2014, 31, 676. <https://doi.org/10.1039/c3np70114j>
  • Stiborová Marie, Frei Eva, Arlt Volker M., Schmeiser Heinz H.: Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid. Xenobiotica 2014, 44, 135. <https://doi.org/10.3109/00498254.2013.848310>
  • Xu Yu-Qiong, Li Xiao-Wei, Liu Guang-Xue, Wang Xuan, Shang Ming-Ying, Li Xiao-Mei, Cai Shao-Qing: Comparative study of the contents of analogues of aristolochic acid in two kinds of Aristolochiae Fructus by high-performance liquid chromatography. J Nat Med 2013, 67, 113. <https://doi.org/10.1007/s11418-012-0664-9>
  • Navarro-García Víctor Manuel, Luna-Herrera Julieta, Rojas-Bribiesca Ma. Gabriela, Álvarez-Fitz Patricia, Ríos María Yolanda: Antibacterial Activity of Aristolochia brevipes against Multidrug-Resistant Mycobacterium tuberculosis. Molecules 2011, 16, 7357. <https://doi.org/10.3390/molecules16097357>
  • Stiborová Marie, Frei Eva, Arlt Volker M., Schmeiser Heinz H.: Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy. Mutation Research/Reviews in Mutation Research 2008, 658, 55. <https://doi.org/10.1016/j.mrrev.2007.07.003>
  • Stiborová M., Frei E., Breuer A., Bieler C.A., Schmeiser H.H.: Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy. Experimental and Toxicologic Pathology 1999, 51, 421. <https://doi.org/10.1016/S0940-2993(99)80033-5>
  • Suau Rafael, López-Romero Juan Manuel, Rico Rodrigo: Sequential bicyclization of biphenyl acetamides promoted by (COCl)2/SnCl4. Total synthesis of 4,5-dioxoaporphines. Tetrahedron 1997, 53, 14397. <https://doi.org/10.1016/S0040-4020(97)00923-X>