Collect. Czech. Chem. Commun. 2003, 68, 711-743
https://doi.org/10.1135/cccc20030711

Synthesis of N4-Alkyl-5-azacytidines and Their Base-Pairing with Carbamoylguanidines - A Contribution to Explanation of the Mutagenicity of 2'-Deoxy-5-azacytidine

Alois Pískala*, Naeem B. Hanna, Milena Masojídková, Miroslav Otmar, Pavel Fiedler and Karel Ubik

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic

Individual author index pages


Other CCCC articles of these authors

  • Petr Alexander, Antonín Holý and Milena Masojídková
    Synthesis of N3-substituted isoguanine derivatives of acyclic nucleotide phosphonates
    Symposium Series 1999, Vol. 2, pp. 263–265 [Abstract]
    Published online 2016-05-08 23:32:12
  • Dana Hocková, Milena Masojídková and Antonín Holý
    Significant influence of (N,N-dimethylamino)methylene protection at N6-position of adenine on regioselectivity of alkylations: Selective synthesis of 7-substituted adenines
    Symposium Series 1999, Vol. 2, pp. 257–259 [Abstract]
    Published online 2016-05-08 23:31:57
  • Miroslav Otmar, Ivan Votruba and Antonín Holý
    An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives
    Symposium Series 1999, Vol. 2, pp. 252–254 [Abstract]
    Published online 2016-05-08 23:31:40
  • Alois Pískala, Naeem B. Hanna, Milena Masojídková, Miroslav Otmar and Pavel Fiedler
    Synthesis of N4-alkyl-5-azacytidines and their base pairing with carbamoylguanidines – a contribution to explanation of the mutagenicity of 5-aza-2'-deoxycytidine
    Symposium Series 1999, Vol. 2, pp. 248–251 [Abstract]
    Published online 2016-05-08 23:31:28
  • Šárka Králíková, Miloš Buděšínský, Milena Masojídková, Ivana Kavenová and Ivan Rosenberg
    Synthesis of α-hydroxyphosphonate analogs of ApA and UV spectroscopy study on their complexes with poly(U)
    Symposium Series 1999, Vol. 2, pp. 89–91 [Abstract]
    Published online 2016-05-08 20:41:40
  • Miroslav Otmar, Milena Masojídková and Antonín Holý
    Synthesis of acyclic 9-deazanucleosides: 9-(2,3-Dihydroxypropyl)-9-deazahypoxanthine
    Symposium Series 1999, Vol. 2, pp. 57–59 [Abstract]
    Published online 2016-05-08 20:40:59
  • Josef Škarda, Lucie Buriánová, Monika Mrazíková, Lenka Klasová, Jana Barthová, Tomislav Barth and Karel Ubik
    New semisynthetic analogs of human insulin and their interaction with IGF-I receptors in mouse mammary explants
    Symposium Series 2001, Vol. 4, pp. 60–62 [Abstract]
    Published online 2016-04-21 09:03:40
  • Vendula Koubová, Jana Barthová, Tomislav Barth, Karel Bezouška, Karel Ubik and Václav Kašička
    Desoctapeptideinsulin: Substrate of α-chymotrypsin
    Symposium Series 1999, Vol. 3, pp. 91–93 [Abstract]
    Published online 2016-03-16 22:55:29
  • Vendula Koubová, Jana Barthová, Václav Kašička, Karel Ubik, Tomislav Barth and Karel Bezouška
    Desoctapeptideinsulin fragments formed by chymotryptic cleavage and suitable for modification of insulin in positions A14 and B16
    Symposium Series 1999, Vol. 3, pp. 88–90 [Abstract]
    Published online 2016-03-16 22:55:25
  • Lenka Klasová, Karel Huml, Jana Barthová, Karel Ubik, Václav Kašička, Josef Škarda, Linda Hauzerová, Tomislav Barth, Axel Wollmer, Dietrich Brandenburg, Jan Ježek and Jiří Velek
    Semisynthetic preparation of human insulin analogs containing N-methylated B24-B25 or B25-B26 peptide bonds
    Symposium Series 1999, Vol. 3, pp. 85–87 [Abstract]
    Published online 2016-03-16 22:55:19
  • Jan Ježek, Jiří Velek, Vlasta Velková, Lenka Klasová, Jana Barthová, Karel Ubik, Václav Kašička, Tomislav Barth, Axel Wollmer, Karel Huml, Linda Hauzerová and Dietrich Brandenburg
    Preparation and characterization of analogs of tetrapeptide B23-B26 and octapeptide B23-B30 of human insulin
    Symposium Series 1999, Vol. 3, pp. 82–84 [Abstract]
    Published online 2016-03-16 22:55:14
  • Hubert Hřebabecký, Michal Šála, Milena Masojídková and Antonín Holý
    Synthesis of racemic 2-hydroxy-4- and 2-hydroxy-5-(hydroxymethyl)cyclohexyl nucleoside analogues
    Symposium Series 2002, Vol. 5, pp. 332–334 [Abstract]
    Published online 2016-01-25 20:42:39
  • Dana Hocková, Antonín Holý and Milena Masojídková
    Synthesis of acyclic nucleotide analogues derived from 5-substituted 2,4-diamino-6-hydroxypyrimidines
    Symposium Series 2002, Vol. 5, pp. 326–327 [Abstract]
    Published online 2016-01-25 20:42:30
  • Michal Česnek, Antonín Holý and Milena Masojídková
    Isomeric guanidinopurine nucleosides and their analogues
    Symposium Series 2002, Vol. 5, pp. 306–307 [Abstract]
    Published online 2016-01-25 20:41:57
  • Petr Čapek, Miroslav Otmar, Milena Masojídková and Antonín Holý
    Cross-coupling reactions of 2,6-dichloro-9-deazapurine
    Symposium Series 2002, Vol. 5, pp. 304–305 [Abstract]
    Published online 2016-01-25 20:41:51
  • Zdeněk Točík, Radek Liboska, Ivan Barvík, Jr., Miloš Buděšínský, Milena Masojídková, Ivana Kavenová and Ivan Rosenberg
    Isosteric phosphonate mono- and oligonucleotides originating from 4',5'-didehydronucleoside precursors: Some synthetic possibilities and limitations
    Symposium Series 2002, Vol. 5, pp. 208–214 [Abstract]
    Published online 2016-01-25 20:40:13
  • Miroslav Otmar, Milena Masojídková, Ivan Votruba and Antonín Holý
    Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds
    Symposium Series 2002, Vol. 5, pp. 38–39 [Abstract]
    Published online 2016-01-25 20:38:21
  • Michal Šála, Hubert Hřebabecký, Milena Masojídková and Antonín Holý
    Synthesis of novel racemic conformationally locked carbocyclic nucleosides
    Symposium Series 2005, Vol. 7, pp. 461–462 [Abstract]
    Published online 2015-11-08 11:58:15
  • Radim Nencka, Ivan Votruba, Hubert Hřebabecký, Eva Tloušťová, Květa Horská, Milena Masojídková and Antonín Holý
    Design and synthesis of 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase
    Symposium Series 2005, Vol. 7, pp. 441–442 [Abstract]
    Published online 2015-11-08 11:57:40
  • Petra Doláková, Milena Masojídková and Antonín Holý
    Synthesis and properties of chiral open-ring acyclic nucleoside bisphosphonates
    Symposium Series 2005, Vol. 7, pp. 395–396 [Abstract]
    Published online 2015-11-08 11:56:15
  • Miroslav Otmar, Milena Masojídková and Antonín Holý
    Acyclic nucleoside phosphonates containing O-substituted hydroxypyridineamines and diamines as nucleobases
    Symposium Series 2005, Vol. 7, pp. 283–285 [Abstract]
    Published online 2015-11-08 11:54:02
  • David Mařák, Miroslav Otmar, Martin Dračínský, Ivan Votruba and Antonín Holý
    Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine
    Symposium Series 2008, Vol. 10, pp. 426–428 [Abstract]
    Published online 2015-10-30 18:44:11
  • Marcela Krečmerová, Antonín Holý, Alois Pískala, Graciela Andrei, Robert Snoeck, Jan Balzarini and Erik De Clercq
    New antiviral agent, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: esters and base-modified derivatives
    Symposium Series 2008, Vol. 10, pp. 196–200 [Abstract]
    Published online 2015-10-30 18:37:33
  • David Mařák, Miroslav Otmar, Martin Dračínský and Marcela Krečmerová
    Nucleosides containing 8-aza-7,9-dideazaxanthine
    Symposium Series 2011, Vol. 12, pp. 383–385 [Abstract]
    Published online 2015-08-20 10:19:50
  • Lucie Janská, Jiří Blažek, David Mařák, Miroslav Otmar and Marcela Krečmerová
    Chemical synthesis of prodrugs derived from 5,6-dihydro-5-azacytosine and its nucleosides using vinyl esters
    Symposium Series 2011, Vol. 12, pp. 349–350 [Abstract]
    Published online 2015-08-20 10:18:34
  • Zlatko Janeba*, Milena Masojídková and Antonín Holý
    Alternative synthesis of 9-{3-[(diisopropoxyphosphoryl)methoxy]-2-hydroxypropyl}adenine and its free phosphonates substituted at the C-8 position of purine base
    2010, Vol. 75, Issue 3, pp. 371–381 [Abstract]
  • Michal Šála, Hubert Hřebabecký*, Martin Dračínský, Milena Masojídková, Armando M. De Palma, Johan Neyts and Antonín Holý
    Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene
    2010, Vol. 75, Issue 1, pp. 1–20 [Abstract]
  • Angelina Andronova, Florence Szydlo, Filip Teplý, Miroslava Tobrmanová, Amandine Volot, Irena G. Stará*, Ivo Starý*, Lubomír Rulíšek, David Šaman, Josef Cvačka, Pavel Fiedler and Pavel Vojtíšek
    The quest for alternative routes to racemic and nonracemic azahelicene derivatives
    2009, Vol. 74, Issue 1, pp. 189–215 [Abstract]
  • Zuzana Krausová, Petr Sehnal, Filip Teplý, Irena G. Stará*, Ivo Starý*, David Šaman, Josef Cvačka and Pavel Fiedler
    Synthesis of Methoxy Substituted Centrally Chiral Triynes as Precursors of Functionalised Nonracemic Helicene-Like Compounds
    2007, Vol. 72, Issue 11, pp. 1499–1522 [Abstract]
  • Marcela Krečmerová*, Antonín Holý and Milena Masojídková
    Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position
    2007, Vol. 72, Issue 7, pp. 927–951 [Abstract]
  • Michal Česnek*, Milena Masojídková, Antonín Holý, Veronika Šolínová, Dušan Koval and Václav Kašička
    Synthesis and Properties of 2-Guanidinopurines
    2006, Vol. 71, Issue 9, pp. 1303–1319 [Abstract]
  • Hubert Hřebabecký*, Milena Masojídková, Martin Dračínský and Antonín Holý
    Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 3-(Hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol
    2006, Vol. 71, Issue 6, pp. 871–888 [Abstract]
  • Michal Šála, Hubert Hřebabecký*, Milena Masojídková and Antonín Holý
    Synthesis of Novel Racemic Conformationally Locked Carbocyclic Nucleosides Derived from 7-Substituted Bicyclo[2.2.1]hept-5-ene-2,2-dimethanols
    2006, Vol. 71, Issue 5, pp. 635–649 [Abstract]
  • Marcela Krečmerová*, Milena Masojídková and Antonín Holý
    Preparation of C-5 Substituted Cidofovir Derivatives
    2006, Vol. 71, Issue 4, pp. 579–594 [Abstract]
  • Silvie Vrbovská*, Antonín Holý, Radek Pohl and Milena Masojídková
    Bifunctional Acyclic Nucleoside Phosphonates. 1. Symmetrical 1,3-Bis[(phosphonomethoxy)propan-2-yl] Derivatives of Purines and Pyrimidines
    2006, Vol. 71, Issue 4, pp. 543–566 [Abstract]
  • Šárka Chalupová*, Antonín Holý and Milena Masojídková
    Synthesis of N4-Substituted Derivatives of 1-[2-(Phosphonomethoxy)ethyl]cytosine and Its Diisopropyl Ester as a Model Reaction for the Synthesis of N4-Substituted Derivatives of Cidofovir
    2005, Vol. 70, Issue 12, pp. 2066–2074 [Abstract]
  • Šárka Chalupová*, Antonín Holý and Milena Masojídková
    Synthesis of Some N4-Substituted Derivatives of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir)
    2005, Vol. 70, Issue 12, pp. 2053–2065 [Abstract]
  • Hubert Hřebabecký*, Milena Masojídková and Antonín Holý
    Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 5,5- and 6,6-Bis(hydroxymethyl)bicyclo[2.2.1]heptan-2-ol
    2005, Vol. 70, Issue 4, pp. 519–538 [Abstract]
  • Dana Hocková*, Milena Masojídková and Antonín Holý
    Sonogashira Cross-Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6-[(Phosphonomethoxy)alkynyl]- and 6-[(Phosphonomethoxy)alkyl]pyrimidines
    2005, Vol. 70, Issue 2, pp. 247–258 [Abstract]
  • Hubert Hřebabecký*, Milena Masojídková and Antonín Holý
    Synthesis of Racemic 9-(6- and 2,6-Substituted 9H-Purin-9-yl)-5-oxatricyclo[4.2.1.03,7]nonane-3-methanols, Novel Conformationally Locked Carbocyclic Nucleosides
    2005, Vol. 70, Issue 1, pp. 103–123 [Abstract]
  • Zuzana Alexandrová, Irena G. Stará*, Petr Sehnal, Filip Teplý, Ivo Starý*, David Šaman and Pavel Fiedler
    Synthetic Studies Toward Chiral Aromatic Triynes as Key Substrates for the Asymmetric Synthesis of Helicene-Like Molecules
    2004, Vol. 69, Issue 12, pp. 2193–2211 [Abstract]
  • Marcela Krečmerová*, Milena Masojídková and Antonín Holý
    Synthesis of N9- and N7-[2-Hydroxy-3-(phosphonomethoxy)propyl] Derivatives of N6-Substituted Adenines, 2,6-Diaminopurines and Related Compounds
    2004, Vol. 69, Issue 10, pp. 1889–1913 [Abstract]
  • Michal Šála, Hubert Hřebabecký*, Milena Masojídková and Antonín Holý
    Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Pyrimidine C-Nucleoside Analogues
    2004, Vol. 69, Issue 4, pp. 918–932 [Abstract]
  • Alois Pískala*, Naeem B. Hanna, Milena Masojídková, Pavel Fiedler and Ivan Votruba
    Synthesis of N4-Amino and N4-Hydroxy Derivatives of 5-Azacytidine. A Facile Rearrangement of the N4-Amino Derivative to 5-(3-β-D-Ribofuranosylureido)-1H-1,2,4-triazole
    2004, Vol. 69, Issue 4, pp. 905–917 [Abstract]
  • Pavel Fiedler and Otto Exner*
    Conformation of Aromatic Carbonyl Derivatives: An Infrared Study
    2004, Vol. 69, Issue 4, pp. 797–810 [Abstract]
  • Hubert Hřebabecký*, Milena Masojídková and Antonín Holý
    Synthesis of Purine Nucleoside Analogues Derived from Carbocyclic 5-C-(Hydroxymethyl)hexopyranoses
    2004, Vol. 69, Issue 2, pp. 435–452 [Abstract]
  • Michal Česnek*, Antonín Holý and Milena Masojídková
    New 2-Alkynyl Derivatives of the Acyclic Nucleoside 9-(2,3-Dihydroxypropyl)adenine and Their 6-Guanidinopurine Counterparts as Potential Effectors of Adenosine Receptors
    2003, Vol. 68, Issue 11, pp. 2201–2218 [Abstract]
  • Marcela Krečmerová*, Miloš Buděšínský, Milena Masojídková and Antonín Holý
    Synthesis of Optically Active N6-Alkyl Derivatives of (R)-3-(Adenin-9-yl)-2-hydroxypropanoic Acid and Related Compounds
    2003, Vol. 68, Issue 5, pp. 931–950 [Abstract]
  • Irena G. Stará*, Ivo Starý*, Adrian Kollárovič, Filip Teplý, David Šaman and Pavel Fiedler
    Synthesis of Helicene Scaffolds via [2+2+2] Cycloisomerization of Aromatic Triynes
    2003, Vol. 68, Issue 5, pp. 917–930 [Abstract]
  • Petr Čapek, Miroslav Otmar*, Milena Masojídková, Ivan Votruba and Antonín Holý
    A Facile Synthesis of 9-Deaza Analogue of Olomoucine
    2003, Vol. 68, Issue 4, pp. 779–791 [Abstract]
  • Hubert Hřebabecký*, Milena Masojídková and Antonín Holý
    Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Nucleoside Analogues
    2002, Vol. 67, Issue 11, pp. 1681–1699 [Abstract]
  • Gabriel Birkuš, Ivan Votruba*, Miroslav Otmar and Antonín Holý
    Interactions of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) Diphosphate with DNA Polymerases α, δ and ε*
    2001, Vol. 66, Issue 11, pp. 1698–1706 [Abstract]
  • Antonín Holý*, Ivan Votruba, Eva Tloušťová and Milena Masojídková
    Synthesis and Cytostatic Activity of N-[2-(Phosphonomethoxy)alkyl] Derivatives of N6-Substituted Adenines, 2,6-Diaminopurines and Related Compounds
    2001, Vol. 66, Issue 10, pp. 1545–1592 [Abstract]
  • Zlatko Janeba*, Antonín Holý and Milena Masojídková
    Transformation of 8-[(2-Hydroxyalkyl)sulfanyl]adenines to 6-Amino-7H-purin-8(9H)-one Derivatives
    2001, Vol. 66, Issue 9, pp. 1393–1406 [Abstract]
  • Zlatko Janeba*, Antonín Holý and Milena Masojídková
    Synthesis of 8-Amino- and N-Substituted 8-Aminoadenine Derivatives of Acyclic Nucleoside and Nucleotide Analogs
    2001, Vol. 66, Issue 3, pp. 517–532 [Abstract]
  • Miroslav Otmar*, Lucie Poláková, Milena Masojídková and Antonín Holý
    A Facile Synthesis of Azetidin-2-ylphosphonic Acid and Its 1-Alkyl Derivatives
    2001, Vol. 66, Issue 3, pp. 507–516 [Abstract]
  • Miroslav Otmar*, Milena Masojídková, Ivan Votruba and Antonín Holý
    An Alternative Synthesis of HPMPC and HPMPA Diphosphoryl Derivatives
    2001, Vol. 66, Issue 3, pp. 500–506 [Abstract]
  • Petr Alexander*, Antonín Holý, Miloš Buděšínský and Milena Masojídková
    Synthesis of Acyclic Nucleotide Analogues Derived from N3-Substituted Isoguanine
    2000, Vol. 65, Issue 11, pp. 1713–1725 [Abstract]
  • Zlatko Janeba*, Antonín Holý and Milena Masojídková
    Synthesis of Acyclic Nucleoside and Nucleotide Analogs Derived from 6-Amino-7H-purine-8(9H)-thione and 8-(Methylsulfanyl)adenine
    2000, Vol. 65, Issue 11, pp. 1698–1712 [Abstract]
  • Zlatko Janeba*, Antonín Holý and Milena Masojídková
    Synthesis of Acyclic Nucleoside and Nucleotide Analogs Derived from 6-Amino-7H-purin-8(9H)-one
    2000, Vol. 65, Issue 7, pp. 1126–1144 [Abstract]
  • Kateřina Meszárosová, Antonín Holý* and Milena Masojídková
    Synthesis of Acyclic Adenine 8,N-Anhydronucleosides
    2000, Vol. 65, Issue 7, pp. 1109–1125 [Abstract]
  • Irena G. Stará*, Adrian Kollárovič, Filip Teplý, Ivo Starý*, David Šaman and Pavel Fiedler
    Synthesis of Aromatic Triynes as Precursors to Helicene Derivatives
    2000, Vol. 65, Issue 4, pp. 577–609 [Abstract]
  • Pavel Fiedler, Jiří Kulhánek, Michèle Decouzon, Jean-François Gal, Pierre-Charles Maria and Otto Exner*
    Steric Effects and Steric Inhibition of Resonance in Isopropylbenzoic Acids in the Gas Phase and in Solution
    1999, Vol. 64, Issue 9, pp. 1433–1447 [Abstract]
  • Dana Hocková*, Milena Masojídková and Antonín Holý
    7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine
    1999, Vol. 64, Issue 8, pp. 1316–1324 [Abstract]
  • Irena G. Stará*, Ivo Starý*, Adrian Kollárovič, Filip Teplý, David Šaman and Pavel Fiedler
    Coupling Reactions of ortho-Substituted Halobenzenes with Alkynes. The Synthesis of Phenylacetylenes and Symmetrical or Unsymmetrical 1,2-Diphenylacetylenes
    1999, Vol. 64, Issue 4, pp. 649–672 [Abstract]
  • Hubert Hřebabecký, Milena Masojídková and Antonín Holý
    Synthesis of Carba Analogues of Deoxy-4-C-(hydroxymethyl)pentofuranoses, Intermediates in the Synthesis of Carbocyclic Nucleosides
    1998, Vol. 63, Issue 12, pp. 2044–2064 [Abstract]
  • Gabriel Birkuš, Pavel Kramata, Ivan Votruba, Berta Otová, Miroslav Otmar and Antonín Holý
    Nonproteolyzed Form of DNA-Polymerase ε from T-Cell Spontaneous Lymphoma of Sprague-Dawley Inbred Rat: Isolation and Characterization
    1998, Vol. 63, Issue 5, pp. 723–731 [Abstract]
  • Naeem B. Hanna, Milena Masojídková and Alois Pískala
    Synthesis and Biological Activity of N4-Methyl-5-azacytidines
    1998, Vol. 63, Issue 5, pp. 713–722 [Abstract]
  • Naeem B. Hanna, Milena Masojídková, Pavel Fiedler and Alois Pískala
    Synthesis of Some 6-Substituted 5-Azacytidines
    1998, Vol. 63, Issue 2, pp. 222–230 [Abstract]
  • Mária Haladová, Eva Eisenreichová, Pavel Mučaji, Miloš Buděšínský and Karel Ubik
    Steroidal Saponins from Lilium candidum L.
    1998, Vol. 63, Issue 2, pp. 205–210 [Abstract]
  • Hubert Hřebabecký, Miloš Buděšínský, Milena Masojídková, Zdeněk Havlas and Antonín Holý
    1-(3,5-O-Alkylidene-2-deoxy-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)uracils
    1997, Vol. 62, Issue 6, pp. 957–970 [Abstract]
  • Michal Hocek, Milena Masojídková and Antonín Holý
    Synthesis of Acyclic Nucleotide Analogues Derived from 6-Hetarylpurines via Cross-Coupling Reactions of 9-[2-(Diethoxyphosphonylmethoxy)ethyl]-6-iodopurine with Hetaryl Organometallic Reagents
    1997, Vol. 62, Issue 1, pp. 136–146 [Abstract]
  • Pavel Kramata, Gabriel Birkuš, Miroslav Otmar, Ivan Votruba and Antonín Holý
    Structural features of acyclic nucleotide analogs conferring inhibitory effects on cellular replicative DNA polymerases
    1996, Vol. 61, Special Issue, pp. S188–S191 [Abstract]
  • Magdalena Endová, Milena Masojídková and Ivan Rosenberg
    Synthesis of some derivatives of 1-[2-deoxy-3,5-O-(1-diethylphosphono)alkylidene-β-D-threo-pentofuranosyl]thymine substituted in the ω-position of the alkylidene moiety
    1996, Vol. 61, Special Issue, pp. S167–S170 [Abstract]
  • Miroslav Otmar, Milena Masojídková and Antonín Holý
    Two synthetic approaches to 9-deaza analogues of 9-(2,3-dihydroxypropyl)adenine (DHPA)
    1996, Vol. 61, Special Issue, pp. S49–S51 [Abstract]
  • Alois Pískala, Milena Masojídková and David Šaman
    Preparation of some derivatives of 5-azacytidine and 2'-deoxy-5-azacytidine
    1996, Vol. 61, Special Issue, pp. S23–S25 [Abstract]
  • Pavel Mučaji, Mária Haladová, Eva Eisenreichová, Miloš Buděšínský and Karel Ubik
    Jatropham 5-O-β-D-Glucopyranoside from Lilium candidum L.
    1996, Vol. 61, Issue 11, pp. 1662–1664 [Abstract]
  • Dana Hocková, Milena Masojídková and Antonín Holý
    "Abbreviated" NAD+ Analogues Containinga Phosphonate Function
    1996, Vol. 61, Issue 10, pp. 1538–1548 [Abstract]
  • Michal Hocek, Milena Masojídková, Antonín Holý, Graciela Andrei, Robert Snoeck, Jan Balzarini and Erik De Clercq
    Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines
    1996, Vol. 61, Issue 10, pp. 1525–1537 [Abstract]
  • Daniel Alexander, Petr Holý, Pavel Fiedler, Zdeněk Havlas and Jiří Závada
    Symmetrical Tris(4,6-diamino-5-methylene-2-pyrimidones): New Building Blocks for Self-Assembly of Hollow Spherical Supramolecules Locked by Hydrogen Bonds
    1996, Vol. 61, Issue 10, pp. 1464–1472 [Abstract]
  • Hana Chodounská, Alexander Kasal, David Šaman and Karel Ubik
    One-Pot Deuteration and Reduction of Ketones in the Synthesis of [16,16,17-2H3]-Epitestosterone
    1996, Vol. 61, Issue 7, pp. 1037–1046 [Abstract]
  • Radek Liboska, Milena Masojídková and Ivan Rosenberg
    Carbocyclic Phosphonate-Based Nucleotide Analogs Related to PMEA II. Racemic cis-Configured Derivatives
    1996, Vol. 61, Issue 5, pp. 778–790 [Abstract]
  • Ladislav Novotný, Anna Vachálková and Alois Pískala
    Investigation of the Polarographic Properties and Potential Carcinogenity of Some Hydroxyurea Derivatives by DC Polarography
    1996, Vol. 61, Issue 4, pp. 656–662 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký, Milena Masojídková and Antonín Holý
    2',3'-Dideoxy- and 3'-Azido-2',3'-dideoxynucleosides of 5-Phenyl-2(1H)-pyrimidinone. Preparation of 2',3'-Dideoxypentofuranoses
    1996, Vol. 61, Issue 3, pp. 478–488 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký, Milena Masojídková and Antonín Holý
    Synthesis of 5-Phenyl-2(1H)-pyrimidinone Nucleosides
    1996, Vol. 61, Issue 3, pp. 458–477 [Abstract]
  • Zlatko Janeba, Antonín Holý, Hana Votavová and Milena Masojídková
    Intramolecular Cyclization of Some Acyclic Nucleoside Analogs
    1996, Vol. 61, Issue 3, pp. 442–457 [Abstract]
  • Radek Liboska, Milena Masojídková and Ivan Rosenberg
    Carbocyclic Phosphonate-Based Nucleotide Analogs Related to PMEA. I. Racemic trans-Configured Derivatives
    1996, Vol. 61, Issue 2, pp. 313–332 [Abstract]
  • Ladislav Novotný, Anna Vachálková and Alois Pískala
    Polarographic Reduction and Potential Carcinogenity of Substituted 1,3,5-Triazine Nucleosides
    1995, Vol. 60, Issue 9, pp. 1469–1475 [Abstract]
  • Antonín Holý, Hana Dvořáková and Milena Masojídková
    Synthesis of Enantiomeric N-(2-Phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases. II. The Synthon Approach
    1995, Vol. 60, Issue 8, pp. 1390–1409 [Abstract]
  • Václav Suchý, Miloš Buděšínský, Karel Ubik, Daniel Grančai and Vlasta Földešiová
    NMR Determination of the Structure of Peracetylated Icariside B2 from Veratrum Lobelianum BERNH.
    1995, Vol. 60, Issue 8, pp. 1380–1385 [Abstract]
  • Antonín Holý and Milena Masojídková
    Synthesis of Enantiomeric N-(2-Phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases. I. The Stepwise Approach
    1995, Vol. 60, Issue 7, pp. 1196–1212 [Abstract]
  • Jan Ježek, Vlasta Velková, Václav Kašička, Zdeněk Prusík, Karel Ubik, Klaudie Bartová and Michael Mareš
    Side Reaction During the Deprotection of Cys(Acm)-Containing Peptides with Iodine. Synthesis of Disulfide Fragments from Cathepsin D Structure
    1995, Vol. 60, Issue 6, pp. 1042–1049 [Abstract]
  • Michal Hocek, Milena Masojídková and Antonín Holý
    Synthesis of Acyclic Nucleotide Analogues Derived from 2-(Aminomethyl)adenine and 2-(Aminomethyl)hypoxanthine
    1995, Vol. 60, Issue 5, pp. 875–882 [Abstract]
  • Marcela Krečmerová, Antonín Holý and Milena Masojídková
    Synthesis of 3-(4-Pyridinyl)-, 3-(2-Chloro-4-pyridinyl)- and 3-(2-Amino-4-pyridinyl)propoxymethanephosphonic Acid
    1995, Vol. 60, Issue 4, pp. 670–680 [Abstract]
  • Dana Hocková, Milena Masojídková, Miloš Buděšínský and Antonín Holý
    Acyclic Nucleoside and Nucleotide Analogs Derived from 2-Azaadenine
    1995, Vol. 60, Issue 2, pp. 224–236 [Abstract]
  • Ivan Votruba, Antonín Holý, Hana Dvořáková, Jaroslav Günter, Dana Hocková, Hubert Hřebabecký, Tomas Cihlar and Milena Masojídková
    Synthesis of 2-Deoxy-β-D-ribonucleosides and 2,3-Dideoxy-β-D-pentofuranosides on Immobilized Bacterial Cells
    1994, Vol. 59, Issue 10, pp. 2303–2330 [Abstract]
  • Petr Alexander, Antonín Holý and Milena Masojídková
    Synthesis of 9-(2-Phosphinomethoxyethyl)adenine and Related Compounds
    1994, Vol. 59, Issue 8, pp. 1870–1878 [Abstract]
  • Petr Alexander, Antonín Holý and Milena Masojídková
    Preparation of 9-(2-Phosphonomethoxyethyl)adenine Esters as Potential Prodrugs
    1994, Vol. 59, Issue 8, pp. 1853–1869 [Abstract]
  • Ladislav Novotný, Anna Vachálková and Alois Pískala
    Polarographic Reduction and Potential Carcinogenity of Synthetic 1,3,5-Triazine Bases and Nucleosides
    1994, Vol. 59, Issue 7, pp. 1691–1698 [Abstract]
  • Maria Spassova, Hana Dvořáková, Antonín Holý, Miloš Buděšínský and Milena Masojídková
    Synthesis of N-(3-Azido-2-hydroxypropyl), N-(3-Phthalimido-2-hydroxypropyl) and N-(3-Amino-2-hydroxypropyl) Derivatives of Heterocyclic Bases
    1994, Vol. 59, Issue 5, pp. 1153–1174 [Abstract]
  • Miroslav Otmar, Ivan Rosenberg, Milena Masojídková and Antonín Holý
    [5-(9-Adeninyl)-5'-deoxy-L-pentofuranosyl]phosphonates: Conformationally restricted nucleotide analogs related to (S)-HPMPA
    1993, Vol. 58, Special Issue, pp. S256–S258 [Abstract]
  • Alois Pískala, Milena Masojídková, David Šaman and Pavel Fiedler
    Structure of 5-azacytosine nucleosides in acid solutions
    1993, Vol. 58, Special Issue, pp. S26–S28 [Abstract]
  • Miroslav Otmar, Ivan Rosenberg, Milena Masojídková and Antonín Holý
    [5-(Adenin-9-yl)-5-deoxy-L-pentofuranosyl]phosphonates - A Novel Type of Nucleotide Analogs Related to HPMPA. II. Synthesis of L-ribo and L-xylo Configurated Derivatives by Recyclization of Diethyl (5-RS)-[1,2-O-Isopropylidene-5-O-methanesulfonyl-D-pentofuranos-5-C-yl]phosphonates under Acidic Conditions
    1993, Vol. 58, Issue 9, pp. 2180–2196 [Abstract]
  • Miroslav Otmar, Ivan Rosenberg, Milena Masojídková and Antonín Holý
    [5-(Adenin-9-yl)-5-deoxypentofuranosyl]phosphonates - A Novel Type of Nucleotide Analogs Related to HPMPA. I. Derivatives with L-arabino, D-arabino, 2-Deoxy-L-erythro and 2-Deoxy-L-threo Configuration
    1993, Vol. 58, Issue 9, pp. 2159–2179 [Abstract]
  • Hana Dvořáková, Antonín Holý, Ivan Votruba and Milena Masojídková
    Synthesis and Biological Effects of Acyclic Analogs of Deazapurine Nucleosides
    1993, Vol. 58, Issue 3, pp. 629–648 [Abstract]
  • Marcela Krečmerová, Hubert Hřebabecký, Milena Masojídková and Antonín Holý
    Preparation of Purine 2'-Deoxy-5'-O-phosphonomethylnucleosides and 2'-Deoxy-3'-O-phosphonomethylnucleosides
    1993, Vol. 58, Issue 2, pp. 421–434 [Abstract]
  • Karel Stránský, Marta Semerdžieva, Miroslav Otmar, Želimír Procházka, Miloš Buděšínský, Karel Ubik, Jitka Kohoutová and Ludvík Streinz
    Antifungal Antibiotic from the Mushroom Agrocybe aegerita (BRIG.) SING.
    1992, Vol. 57, Issue 3, pp. 590–603 [Abstract]
  • Karel Stránský, Milan Streibl and Karel Ubik
    Unusual alkanes pattern of some plant cuticular waxes
    1991, Vol. 56, Issue 5, pp. 1123–1129 [Abstract]
  • Mária Haladová, Eva Eisenreichová, Anna Bučková, Jozef Tomko, Dušan Uhrín and Karel Ubik
    Dimeric pyrroline alkaloids from Lilium candium L.
    1991, Vol. 56, Issue 2, pp. 436–438 [Abstract]
  • Alois Pískala, Petr Alexander and Jiří Burkhard
    Synthesis of some anomeric 4,6-disubstituted-1-(2-deoxy-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-ones
    1990, Vol. 55, Special Issue, pp. S53–S56 [Abstract]
  • Ivan Stibor, David Šaman and Pavel Fiedler
    Synthesis and conformation of some 6-aminomethyluracil amides
    1990, Vol. 55, Issue 11, pp. 2731–2737 [Abstract]
  • Otakar Červinka, Aleš Svatoš and Milena Masojídková
    Preparation of three diastereoisomers of 2-(1-methyl-1-phenylethyl)-5-methylcyclohexan-1-ol from (R)-(+)-pulegone
    1990, Vol. 55, Issue 2, pp. 491–498 [Abstract]
  • Alois Pískala, Naeem B. Hanna, Jaroslav Zajíček and Alois Čihák
    Synthesis, molecular conformation and biological activity of 6-amino-5-azacytidine
    1989, Vol. 54, Issue 9, pp. 2502–2512 [Abstract]
  • Ivan Rosenberg, Antonín Holý and Milena Masojídková
    Phosphonylmethoxyalkyl and phosphonylalkyl derivatives of adenine
    1988, Vol. 53, Issue 11, pp. 2753–2777 [Abstract]
  • Hana Dvořáková, Antonín Holý and Milena Masojídková
    Fluorescent analogues of acyclic inhibitors of S-adenosyl-L-homocysteine hydrolase
    1988, Vol. 53, Issue 8, pp. 1779–1794 [Abstract]
  • Otto Exner and Pavel Fiedler
    Conformation and electronic structure of aromatic chloroformates
    1987, Vol. 52, Issue 4, pp. 970–979 [Abstract]
  • Jiří Klinot, Milan Jirsa, Eva Klinotová, Karel Ubik and Jiří Protiva
    Isolation of (23R) 3α, 7α,23-trihydroxy-5β-cholan-24-oic (β-phocaecholic) acid from duck bile. 1H NMR spectra of its derivatives
    1986, Vol. 51, Issue 8, pp. 1722–1730 [Abstract]
  • Maria K. Spassova, Antonín Holý and Milena Masojídková
    Ribonucleosides of 3-amino- and 3,5-diaminopyrazole-4-carboxylic acid and their open-chain analogues: Synthesis and reactions
    1986, Vol. 51, Issue 7, pp. 1512–1531 [Abstract]
  • Milena Masojídková, Jaroslav Zajíček, Miloš Buděšínský, Ivan Rosenberg and Antonín Holý
    Conformational study on ribonucleoside O-phosphonylmethyl derivatives by 1H NMR spectroscopy
    1985, Vol. 50, Issue 8, pp. 1899–1905 [Abstract]
  • Karel Konečný, Milan Streibl, Soňa Vašíčková, Miloš Buděšínský, David Šaman, Karel Ubik and Vlastimil Herout
    Constituents of the liverwort Bazzania trilobata of Czech origin
    1985, Vol. 50, Issue 1, pp. 80–93 [Abstract]
  • Zdeněk Friedl, Pavel Fiedler, Ján Biroš, Věra Uchytilová, Igor Tvaroška, Stanislav Böhm and Otto Exner
    Electrostatic effects on conformational equilibria: Solvation enthalpies and the reaction field theory
    1984, Vol. 49, Issue 9, pp. 2050–2069 [Abstract]
  • Alois Pískala, Abdul Hamid Rehan and Manfred Schlosser
    Wittig-Reaktion von Triphenylphosphonio-alkyliden mit substituierten Benzaldehyden: Hammett-Beziehung und teilweise Reversibilität der Addukt-bildung
    1983, Vol. 48, Issue 12, pp. 3539–3551 [Abstract]
  • Otto Exner, Zdeněk Friedl and Pavel Fiedler
    Electrostatic effects on conformational equilibria: Alkyl 2-cyanobenzoates and 3-cyanopropenoates
    1983, Vol. 48, Issue 11, pp. 3086–3096 [Abstract]
  • Karel Konečný, Karel Ubik, Soňa Vašíčková, Milan Streibl and Vlastimil Herout
    Constituents of the liverwort Lophocolea heterophylla
    1982, Vol. 47, Issue 11, pp. 3164–3169 [Abstract]
  • Jaromír Kaválek, Pavel Fiedler, Zlata Papoušková and Otto Exner
    The confirmation of trisubstituted ureas and thioureas in solution
    1982, Vol. 47, Issue 1, pp. 35–44 [Abstract]
  • Josef Jizba, Věra Laudová, Zdeněk Samek, Karel Ubik and Ladislav Novotný
    Components of Senecio nemorensis var. subdecurens
    1981, Vol. 46, Issue 4, pp. 1048–1053 [Abstract]
  • Jiří Jarý, Milena Masojídková, Ivan Kozák, Miroslav Marek and Jan Staněk, Jr.
    The preparation of 3-amino-3-deoxy-1,2-O-isopropylidene-α-L-erythrofuranose, 3-amino-3-deoxy-1,2-O-isopropylidene-β-D-threofuranose and their derivatives
    1980, Vol. 45, Issue 12, pp. 3378–3390 [Abstract]
  • Zdeněk Friedl, Pavel Fiedler and Otto Exner
    Electrostatic effects on conformational equilibria. Solvent dependence
    1980, Vol. 45, Issue 5, pp. 1351–1360 [Abstract]
  • Otto Exner and Pavel Fiedler
    A refined empirical model of the sigma-inductive effect
    1980, Vol. 45, Issue 4, pp. 1251–1268 [Abstract]
  • Jiří Mollin, Pavel Fiedler, Václav Jehlička and Otto Exner
    The conformation of substituted hydroxyureas and hydroxythioureas in solution
    1979, Vol. 44, Issue 3, pp. 895–907 [Abstract]
  • Miroslav Holub, Zdeněk Samek, Soňa Vašíčková and Milena Masojídková
    11-Hydroxy-1βH,5βH,6αH,7αH-guaian-6,12-olides: Relative and absolute configuration of the sesquiterpenic lactones montanolide, isomontanolide, acetylisomontanolide and related substances
    1978, Vol. 43, Issue 9, pp. 2444–2470 [Abstract]
  • Miroslav Svoboda, Miroslava Synáčková, Zdeněk Samek, Pavel Fiedler and Zdeněk Arnold
    N,N-Dimethyl-N-alkylammoniodiformylmethylides: New group of stabilised aliphatic ylides
    1978, Vol. 43, Issue 5, pp. 1261–1275 [Abstract]