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Collect. Czech. Chem. Commun. 2006, 71, 788-803
https://doi.org/10.1135/cccc20060788

Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl-2-(hydroxymethyl)purine Bases and Nucleosides

Peter Šilhár, Radek Pohl, Ivan Votruba, Blanka Klepetářová and Michal Hocek*

Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 16610 Prague 6, Czech Republic

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  • Kang Fu‐An, Sui Zhihua, Murray William V.: Phosphonium Coupling in the Direct Bond Formations of Tautomerizable Heterocycles via C–OH Bond Activation. Eur J Org Chem 2009, 2009, 461. <https://doi.org/10.1002/ejoc.200801004>
  • Qu Gui-Rong, Mao Zhi-Jie, Niu Hong-Ying, Wang Dong-Chao, Xia Chao, Guo Hai-Ming: Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic Acid Ethyl Esters, (Purin-6-yl)acetates, and 6-Methylpurines through SNAr-Based Reactions of 6-Halopurines with Ethyl Acetoacetate. Org. Lett. 2009, 11, 1745. <https://doi.org/10.1021/ol9002256>
  • Šilhár Peter, Hocek Michal, Pohl Radek, Votruba Ivan, Shih I-hung, Mabery Eric, Mackman Richard: Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides. biorg med chem 2008, 16, 2329. <https://doi.org/10.1016/j.bmc.2007.11.067>
  • Bambuch Vítězslav, Otmar Miroslav, Pohl Radek, Masojídková Milena, Holý Antonín: C-Functionalization of 9-deazapurines by cross-coupling reactions. Tetrahedron 2007, 63, 1589. <https://doi.org/10.1016/j.tet.2006.12.008>
  • Silhar Peter, Pohl Radek, Votruba Ivan, Klepetarova Blanka, Hocek Michal: Synthesis of 6‐Amino‐, 6‐Methyl‐ and 6‐Aryl‐2‐(hydroxymethyl)purine Bases and Nucleosides. ChemInform 2006, 37. <https://doi.org/10.1002/chin.200644193>
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